ASPC™

Recombinant
Aryl-Sulfatase Enzyme

Liquid recombinant Aryl-Sulfatase enzyme.
Store at 2-8°C.
For R&D use only. Not for drugs, households, or other uses.

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“The only pure recombinant arylsulfatase for steroid
sulfo-conjugates.”

ASPC™

Specifically designed for selective deconjugation of sulfo-conjugates while leaving 𝛃-glucuronide conjugates intact.

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Product overview

Description

ASPC™ is a recombinant arylsulfatase enzyme that efficiently deconjugates a wide range of sulfated moieties. Unlike most commercially available enzymes, which include glucuronidase enzymes, ASPC™ is a pure sulfatase that enables the hydrolysis of sulfates alone, with no other types of conjugations. 

Conjugation of xenobiotics represents an important biotransformation reaction in humans and animals. Hydrolysis of sulfo-conjugates is particularly relevant in steroid analysis, given that many steroids are converted into a mix of conjugates.

Because of its purity, ASPC™ avoids both conversions and the generation of interfering peaks typically produced by wild-type enzymes. Unlike wild-type versions, recombinant arylsulfatase can reach pure arylsulfatase activity. It is also significantly more stable, something that is difficult to achieve in wild-type enzymes.Learn about the ASPC benefitsSpecifications

Product Form: Solution, 10% (v/v) glycerol

Storage/Stability: 12 months at 2°C – 8°C

Temperature Range: 50 – 55°C

pH Range: 6.8 - 7.5

Available Presentations

     5mL       10mL   

Resources

Technical Datasheets

Technical DataSheet ASPC

Publications & Posters

Comparison of two aryl sulfatases for targeted mass spectrometric analysis of microbiota derived metabolites

Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host

Development and characterization of an enzyme formulation for sulfatase and glucuronidase hydrolysis in a single step

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