blikka_destello

What we offer

At Blikka Genomics, we are transforming the landscape of DNA and RNA synthesis. Our journey begins with the TdT Synthesis Panel, leading into the Accel-TdT Program where we customize TdT enzymes tailored to your specific DNA synthesis protocols using our advanced protein engineering platform, Cantera.

blikka_destello

What we offer

At Blikka Genomics, we are transforming the landscape of DNA and RNA synthesis. Our journey begins with the TdT Synthesis Panel, leading into the Accel-TdT Program where we customize TdT enzymes tailored to your specific DNA synthesis protocols using our advanced protein engineering platform, Cantera.

  • Proprietary Portfolio of TdT Enzymes Ready for Evolution:
    Commercially available TdT enzymes are not optimized for non-native nucleotide analogs needed for controlled synthesis of DNA/RNA sequences. Blikka Genomics offers a diverse portfolio of proprietary Terminal Deoxynucleotidyl Transferase (TdT) enzymes sourced from artificial chimeric origins. These sequences serve as a robust backbone that can be evolved and tailored to meet specific needs.

  • Protein Engineering Platform:
    Our specialized protein engineering platform, Cantera, leverages over 11 years of experience, employing a structured, data-driven process to generate and optimize enzyme candidates. By integrating deep sequencing for faster learning cycles, Cantera ensures efficient production and delivery of final enzyme products.

  • OEM Licensing and Custom Manufacturing:
    Full access to our proprietary library of TdTs with OEM licensing agreements. Have enzymes manufactured at Blikka with custom labeling requirements or opt for manufacturing at your own facility, integrating advanced enzymatic solutions seamlessly into your production processes.

  • Sustainability Impact:
    The Accel-TdT Program supports sustainable biotechnology by reducing harmful chemical waste and lowering energy consumption, compared to traditional chemical synthesis methods. This not only enhances your research but also contributes to a more sustainable future.
  • Proprietary Portfolio of TdT Enzymes Ready for Evolution:
    Commercially available TdT enzymes are not optimized for non-native nucleotide analogs needed for controlled synthesis of DNA/RNA sequences. Blikka Genomics offers a diverse portfolio of proprietary Terminal Deoxynucleotidyl Transferase (TdT) enzymes sourced from artificial chimeric origins. These sequences serve as a robust backbone that can be evolved and tailored to meet specific needs.

  • Protein Engineering Platform:
    Our specialized protein engineering platform, Cantera, leverages over 11 years of experience, employing a structured, data-driven process to generate and optimize enzyme candidates. By integrating deep sequencing for faster learning cycles, Cantera ensures efficient production and delivery of final enzyme products.

  • OEM Licensing and Custom Manufacturing:
    Full access to our proprietary library of TdTs with OEM licensing agreements. Have enzymes manufactured at Blikka with custom labeling requirements or opt for manufacturing at your own facility, integrating advanced enzymatic solutions seamlessly into your production processes.

  • Sustainability Impact:
    The Accel-TdT Program supports sustainable biotechnology by reducing harmful chemical waste and lowering energy consumption, compared to traditional chemical synthesis methods. This not only enhances your research but also contributes to a more sustainable future.

HOW THE
ACCEL TDT
PROGRAM
WORKS

HOW THE
ACCEL TDT
PROGRAM
WORKS

THE STARTING POINT

TDT SYNTHESIS PANEL


Our versatile panel offers 6 proprietary and engineered Terminal Deoxynucleotidyl Transferase (TdT) enzymes, designed for high coupling efficiency with both natural and modified nucleotides, range of thermostability, and low bias. 

These enzymes serve as a foundation to be tested, and the one that works best for customization in co-development with our Product Engineering team is selected.

blikka_product_tdt

Key Features

FAVICON Blikka

Thermostability: Functions efficiently at different temperatures.


FAVICON Blikka

Compatibility with Blocked Nucleotides: Works effectively with 3’O-NH2 reversibly blocked dNTPs.


FAVICON Blikka

High Coupling Efficiency & Low Bias: Delivers excellent coupling efficiency and low bias with natural DNA nucleotides, modified DNA nucleotides, and natural RNA nucleotides, ensuring high-quality synthesis outcomes​​.


FAVICON Blikka

pH Resistance: Stable and functional across a broad pH range (pH 5-9), providing flexibility in various synthesis conditions​​.

THE STARTING POINT

TDT SYNTHESIS PANEL


Our versatile panel offers 6 proprietary and engineered Terminal Deoxynucleotidyl Transferase (TdT) enzymes, designed for high coupling efficiency with both natural and modified nucleotides, range of thermostability, and low bias. 

These enzymes serve as a foundation to be tested, and the one that works best for customization in co-development with our Product Engineering team is selected.

blikka_product_tdt

Key Features

FAVICON Blikka

Thermostability: Functions efficiently at different temperatures.


FAVICON Blikka

Compatibility with Blocked Nucleotides: Works effectively with 3’O-NH2 reversibly blocked dNTPs.


FAVICON Blikka

High Coupling Efficiency & Low Bias: Delivers excellent coupling efficiency and low bias with natural DNA nucleotides, modified DNA nucleotides, and natural RNA nucleotides, ensuring high-quality synthesis outcomes​​.


FAVICON Blikka

pH Resistance: Stable and functional across a broad pH range (pH 5-9), providing flexibility in various synthesis conditions​​.

PERFORMANCE DATA

DIVERSITY IN TdT BACKGROUNDS +

INCORPORATION OF DNA NATURAL NUCLEOTIDES +

INCORPORATION OF DNA-MODIFIED NUCLEOTIDES +

INCORPORATION OF RNA NATURAL NUCLEOTIDES +

Ready to Transform Your Synthesis Process?

Take the first step towards customizing TdT enzymes for your DNA and RNA synthesis needs. Leverage our proprietary TdT Synthesis Panel and partner with our expert team through the Accel TdT Program to create tailored solutions that enhance your research.

Ready to Transform Your Synthesis Process?

Take the first step towards customizing TdT enzymes for your DNA and RNA synthesis needs. Leverage our proprietary TdT Synthesis Panel and partner with our expert team through the Accel TdT Program to create tailored solutions that enhance your research.